| 2024 Game Log: 80–82 (Home: 42–39; Away: 38–43) |
March/April: 14–17 (Home: 8–9; Away: 6–8)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 1 | March 28 | Blue Jays | 2–8 | Berríos (1–0) | Eflin (0–1) | — | 25,025 | 0–1 | L1 |
| 2 | March 29 | Blue Jays | 8–2 | Civale (1–0) | Bassitt (0–1) | — | 18,653 | 1–1 | W1 |
| 3 | March 30 | Blue Jays | 5–1 | Littell (1–0) | Kikuchi (0–1) | — | 18,905 | 2–1 | W2 |
| 4 | March 31 | Blue Jays | 2–9 | White (1–0) | Armstrong (0–1) | — | 14,875 | 2–2 | L1 |
| 5 | April 1 | Rangers | 3–9 | Dunning (1–0) | Pepiot (0–1) | — | 14,144 | 2–3 | L2 |
| 6 | April 2 | Rangers | 5–2 | Eflin (1–1) | Heaney (0–1) | — | 11,697 | 3–3 | W1 |
| 7 | April 3 | Rangers | 1–4 | Eovaldi (1–0) | Civale (1–1) | — | 18,881 | 3–4 | L1 |
| 8 | April 5 | @ Rockies | 7–10 | Beeks (1–0) | Fairbanks (0–1) | — | 48,399 | 3–5 | L2 |
| 9 | April 6 | @ Rockies | 8–6 | Cleavinger (1–0) | Beeks (1–1) | Poche (1) | 29,238 | 4–5 | W1 |
| 10 | April 7 | @ Rockies | 3–2 | Pepiot (1–1) | Hudson (0–2) | Armstrong (1) | 25,566 | 5–5 | W2 |
| 11 | April 8 | @ Angels | 1–7 | Anderson (2–0) | Eflin (1–2) | — | 18,748 | 5–6 | L1 |
| 12 | April 9 | @ Angels | 6–4 | Civale (2–1) | Sandoval (1–2) | Fairbanks (1) | 20,271 | 6–6 | W1 |
| 13 | April 10 | @ Angels | 4–2 | Kelly (1–0) | Soriano (0–2) | Fairbanks (2) | 16,600 | 7–6 | W2 |
| 14 | April 12 | Giants | 2–1 | Cleavinger (2–0) | Winn (0–3) | Fairbanks (3) | 15,146 | 8–6 | W3 |
| 15 | April 13 | Giants | 2–11 | Webb (1–1) | Pepiot (1–2) | — | 17,411 | 8–7 | L1 |
| 16 | April 14 | Giants | 9–4 | Alexander (1–0) | Snell (0–2) | — | 19,470 | 9–7 | W1 |
| 17 | April 15 | Angels | 3–7 | García (1–0) | Maton (0–1) | — | 12,267 | 9–8 | L1 |
| 18 | April 16 | Angels | 7–6 (13) | Cleavinger (3–0) | Fulmer (0–1) | — | 12,160 | 10–8 | W1 |
| 19 | April 17 | Angels | 4–5 | Strickland (1–0) | Fairbanks (0–2) | — | 10,844 | 10–9 | L1 |
| 20 | April 18 | Angels | 2–1 | Pepiot (2–2) | Canning (0–3) | Poche (2) | 10,648 | 11–9 | W1 |
| 21 | April 19 | @ Yankees | 3–5 | Santana (1–0) | Devenski (0–1) | Holmes (8) | 36,055 | 11–10 | L1 |
| 22 | April 20 | @ Yankees | 2–0 (10) | Adam (1–0) | Ferguson (0–3) | Cleavinger (1) | 47,629 | 12–10 | W1 |
| 23 | April 21 | @ Yankees | 4–5 | Gil (1–1) | Civale (2–2) | González (2) | 40,022 | 12–11 | L1 |
| 24 | April 22 | Tigers | 1–7 | Skubal (3–0) | Littell (1–1) | — | 13,522 | 12–12 | L2 |
| 25 | April 23 | Tigers | 2–4 | Faedo (1–1) | Poche (0–1) | Foley (7) | 13,648 | 12–13 | L3 |
| 26 | April 24 | Tigers | 7–5 | Devenski (1–1) | Vest (1–1) | Cleavinger (2) | 13,754 | 13–13 | W1 |
| 27 | April 26 | @ White Sox | 4–9 | Flexen (1–3) | Eflin (1–3) | — | 10,323 | 13–14 | L1 |
| 28 | April 27 | @ White Sox | 7–8 (10) | García (1–2) | Maton (0–2) | — | 28,009 | 13–15 | L2 |
| 29 | April 28 | @ White Sox | 2–4 | Fedde (2–0) | Littell (1–2) | Leasure (1) | 12,669 | 13–16 | L3 |
| 30 | April 29 | @ Brewers | 1–0 | Pepiot (3–2) | Wilson (2–1) | Adam (1) | 20,395 | 14–16 | W1 |
| 31 | April 30 | @ Brewers | 2–8 | Peralta (3–0) | Alexander (1–1) | — | 21,124 | 14–17 | L1 |
|
May: 14–13 (Home: 9–9; Away: 5–4)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 32 | May 1 | @ Brewers | 1–7 | Rea (3–0) | Eflin (1–4) | — | 20,132 | 14–18 | L2 |
| 33 | May 3 | Mets | 10–8 | Armstrong (1–1) | Quintana (1–3) | Adam (2) | 19,077 | 15–18 | W1 |
| 34 | May 4 | Mets | 3–1 | Adam (2–0) | Ottavino (1–1) | Maton (1) | 18,968 | 16–18 | W2 |
| 35 | May 5 | Mets | 7–6 (10) | Ramírez (1–0) | Diekman (1–1) | — | 19,310 | 17–18 | W3 |
| 36 | May 6 | White Sox | 8–2 | Ramírez (2–0) | Clevinger (0–1) | — | 12,042 | 18–18 | W4 |
| 37 | May 7 | White Sox | 5–1 | Eflin (2–4) | Soroka (0–4) | — | 10,872 | 19–18 | W5 |
| 38 | May 8 | White Sox | 1–4 | Flexen (2–3) | Civale (2–3) | Kopech (3) | 12,877 | 19–19 | L1 |
| 39 | May 10 | Yankees | 0–2 | Schmidt (4–1) | Bradley (0–1) | Holmes (12) | 18,041 | 19–20 | L2 |
| 40 | May 11 | Yankees | 7–2 | Littell (2–2) | Cortés Jr. (1–4) | — | 21,308 | 20–20 | W1 |
| 41 | May 12 | Yankees | 6–10 | Gil (4–1) | Alexander (1–2) | — | 20,694 | 20–21 | L1 |
| 42 | May 13 | @ Red Sox | 5–3 | Eflin (3–4) | Crawford (2–2) | Adam (3) | 28,663 | 21–21 | W1 |
| 43 | May 14 | @ Red Sox | 4–5 (12) | Bernardino (2–1) | Rodríguez (0–1) | — | 32,892 | 21–22 | L1 |
| 44 | May 15 | @ Red Sox | 4–3 | Bradley (1–1) | Houck (3–5) | Kelly (1) | 30,016 | 22–22 | W1 |
| 45 | May 16 | @ Red Sox | 7–5 | Rodríguez (1–1) | Jansen (1–1) | Ramírez (1) | 31,704 | 23–22 | W2 |
| 46 | May 17 | @ Blue Jays | 4–3 | Alexander (2–2) | Bassitt (3–6) | Fairbanks (4) | 32,640 | 24–22 | W3 |
| 47 | May 18 | @ Blue Jays | 5–4 | Ramírez (3–0) | Pearson (0–1) | Cleavinger (3) | 34,416 | 25–22 | W4 |
| 48 | May 19 | @ Blue Jays | 2–5 | Manoah (1–1) | Civale (2–4) | Romano (7) | 35,840 | 25–23 | L1 |
| 49 | May 20 | Red Sox | 0–5 | Houck (4–5) | Bradley (1–2) | — | 13,489 | 25–24 | L2 |
| 50 | May 21 | Red Sox | 2–5 | Weissert (2–1) | Adam (2–1) | Jansen (8) | 12,274 | 25–25 | L3 |
| 51 | May 22 | Red Sox | 5–8 | Bello (5–2) | Lovelady (0–2) | — | 13,095 | 25–26 | L4 |
| 52 | May 24 | Royals | 1–8 | Lugo (8–1) | Alexander (2–3) | — | 16,368 | 25–27 | L5 |
| 53 | May 25 | Royals | 4–7 (11) | McArthur (2–2) | Lovelady (0–3) | Anderson (1) | 20,309 | 25–28 | L6 |
| 54 | May 26 | Royals | 4–1 | Cleavinger (4–0) | Wacha (4–5) | Fairbanks (5) | 20,789 | 26–28 | W1 |
| 55 | May 28 | Athletics | 0–3 | Spence (4–2) | Littell (2–3) | Miller (11) | 13,889 | 26–29 | L1 |
| 56 | May 29 | Athletics | 4–3 | Fairbanks (1–2) | Kelly (2–2) | — | 13,167 | 27–29 | W1 |
| 57 | May 30 | Athletics | 6–5 (12) | Lovelady (1–3) | Ferguson (0–1) | — | 15,264 | 28–29 | W2 |
| 58 | May 31 | @ Orioles | 1–3 | Pérez (1–0) | Lovelady (1–4) | Kimbrel (13) | 27,364 | 28–30 | L1 |
|
June: 14–12 (Home: 6–7; Away: 8–5)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 59 | June 1 | @ Orioles | 5–9 | Webb (1–3) | Bradley (1–3) | — | 36,958 | 28–31 | L2 |
| 60 | June 2 | @ Orioles | 4–3 | Armstrong (2–1) | Tate (2–1) | Fairbanks (6) | 32,463 | 29–31 | W1 |
| 61 | June 4 | @ Marlins | 9–5 | Pepiot (4–2) | Luzardo (2–5) | Fairbanks (7) | 9,234 | 30–31 | W2 |
| 62 | June 5 | @ Marlins | 5–3 | Lovelady (2–4) | Garrett (2–1) | Fairbanks (8) | 8,778 | 31–31 | W3 |
| 63 | June 7 | Orioles | 3–6 | Irvin (6–2) | Civale (2–5) | Kimbrel (14) | 17,882 | 31–32 | L1 |
| 64 | June 8 | Orioles | 0–5 | Bradish (2–0) | Bradley (1–4) | — | 20,485 | 31–33 | L2 |
| 65 | June 9 | Orioles | 2–9 | Rodriguez (7–2) | Littell (2–4) | — | 20,386 | 31–34 | L3 |
| 66 | June 10 | Orioles | 2–5 | Burnes (7–2) | Pepiot (4–3) | Kimbrel (15) | 14,686 | 31–35 | L4 |
| 67 | June 11 | Cubs | 5–2 | Devenski (2–1) | Neris (6–1) | — | 15,192 | 32–35 | W1 |
| 68 | June 12 | Cubs | 3–4 | Miller (1–0) | Cleavinger (4–1) | Neris (10) | 16,927 | 32–36 | L1 |
| 69 | June 13 | Cubs | 3–2 | Bradley (2–4) | Leiter Jr. (2–4) | Fairbanks (9) | 19,679 | 33–36 | W1 |
| 70 | June 14 | @ Braves | 3–7 | Sale (9–2) | Littell (2–5) | Iglesias (18) | 41,046 | 33–37 | L1 |
| 71 | June 15 | @ Braves | 2–9 | Morton (4–3) | Pepiot (4–4) | — | 40,480 | 33–38 | L2 |
| 72 | June 16 | @ Braves | 8–6 | Adam (3–1) | Iglesias (0–1) | Fairbanks (10) | 40,211 | 34–38 | W1 |
| 73 | June 18 | @ Twins | 6–7 | Durán (3–2) | Fairbanks (1–3) | — | 17,342 | 34–39 | L1 |
| 74 | June 19 | @ Twins | 3–2 (10) | Adam (4–1) | Alcalá (1–2) | Maton (2) | 20,712 | 35–39 | W1 |
| 75 | June 20 | @ Twins | 7–6 (10) | Fairbanks (2–3) | Jax (3–3) | — | 24,863 | 36–39 | W2 |
| 76 | June 21 | @ Pirates | 10–3 | Poche (1–1) | Mlodzinski (1–3) | — | 26,600 | 37–39 | W3 |
| 77 | June 22 | @ Pirates | 3–4 | Jones (5–6) | Eflin (3–5) | Chapman (2) | 33,040 | 37–40 | L1 |
| 78 | June 23 | @ Pirates | 3–1 | Kelly (2–0) | Holderman (3–1) | Fairbanks (11) | 29,026 | 38–40 | W1 |
| 79 | June 24 | Mariners | 4–3 | Maton (1–2) | Voth (2–2) | Fairbanks (12) | 14,482 | 39–40 | W2 |
| 80 | June 25 | Mariners | 11–3 | Cleavinger (5–1) | Castillo (6–9) | — | 14,034 | 40–40 | W3 |
| 81 | June 26 | Mariners | 2–5 | Kirby (7–5) | Armstrong (2–2) | Thornton (1) | 18,286 | 40–41 | L1 |
| 82 | June 28 | Nationals | 3–1 | Eflin (4–5) | Parker (5–4) | Fairbanks (13) | 14,959 | 41–41 | W1 |
| 83 | June 29 | Nationals | 1–8 | Irvin (6–6) | Civale (2–6) | — | 17,501 | 41–42 | L1 |
| 84 | June 30 | Nationals | 5–0 | Bradley (3–4) | Corbin (1–8) | — | 18,259 | 42–42 | W1 |
|
July: 13–11 (Home: 7–4; Away: 6–7)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 85 | July 2 | @ Royals | 5–1 | Littell (3–5) | Singer (4–5) | — | 16,865 | 43–42 | W2 |
| 86 | July 3 | @ Royals | 2–4 | Wacha (5–6) | Pepiot (4–5) | McArthur (15) | 23,268 | 43–43 | L1 |
| 87 | July 4 | @ Royals | 10–8 | Eflin (5–5) | Marsh (6–6) | Fairbanks (14) | 28,358 | 44–43 | W1 |
| 88 | July 5 | @ Rangers | 0–3 | Lorenzen (5–4) | Baz (0–1) | Yates (12) | 32,175 | 44–44 | L1 |
| 89 | July 6 | @ Rangers | 3–4 | Hernández (2–0) | Kelly (2–1) | Yates (13) | 31,560 | 44–45 | L2 |
| 90 | July 7 | @ Rangers | 2–13 | Eovaldi (6–3) | Littell (3–6) | — | 32,113 | 44–46 | L3 |
| 91 | July 9 | Yankees | 5–3 | Pepiot (5–5) | Rodón (9–7) | Fairbanks (15) | 20,436 | 45–46 | W1 |
| 92 | July 10 | Yankees | 1–2 | Hill (3–0) | Eflin (5–6) | Holmes (20) | 19,246 | 45–47 | L1 |
| 93 | July 11 | Yankees | 5–4 | Kelly (3–1) | Cortés Jr. (4–8) | Fairbanks (16) | 23,438 | 46–47 | W1 |
| 94 | July 12 | Guardians | 2–0 | Bradley (4–4) | Carrasco (3–7) | Adam (4) | 17,290 | 47–47 | W2 |
| 95 | July 13 | Guardians | 2–4 | Sandlin (6–0) | Cleavinger (5–2) | Clase (29) | 19,946 | 47–48 | L1 |
| 96 | July 14 | Guardians | 2–0 | Pepiot (6–5) | Lively (8–5) | Fairbanks (17) | 21,875 | 48–48 | W1 |
| – | July 16 | 94th All-Star Game in Arlington, TX |
| 97 | July 19 | @ Yankees | 1–6 | Cole (3–1) | Eflin (5–7) | — | 47,036 | 48–49 | L1 |
| 98 | July 20 | @ Yankees | 9–1 | Bradley (5–4) | Cortés Jr. (4–9) | — | 43,173 | 49–49 | W1 |
| 99 | July 21 | @ Yankees | 6–4 | Cleavinger (6–2) | Stroman (7–5) | Fairbanks (18) | 45,178 | 50–49 | W2 |
| 100 | July 22 | @ Yankees | 1–6 | Rodón (10–7) | Littell (3–7) | — | 40,824 | 50–50 | L1 |
| 101 | July 23 | @ Blue Jays | 4–2 | Alexander (3–3) | Berríos (8–8) | Fairbanks (19) | 38,575 | 51–50 | W1 |
| 102 | July 24 | @ Blue Jays | 3–6 | Cabrera (3–2) | Adam (4–2) | — | 32,276 | 51–51 | L1 |
| 103 | July 25 | @ Blue Jays | 13–0 | Bradley (6–4) | Bassitt (8–9) | — | 41,148 | 52–51 | W1 |
| 104 | July 26 | Reds | 2–3 (10) | Martinez (4–5) | Rodríguez (1–2) | Díaz (20) | 20,441 | 52–52 | L1 |
| 105 | July 27 | Reds | 4–0 | Littell (4–7) | Abbott (9–7) | — | 23,464 | 53–52 | W1 |
| 106 | July 28 | Reds | 2–1 | Cleavinger (7–2) | Cruz (3–8) | Fairbanks (20) | 19,873 | 54–52 | W2 |
| 107 | July 30 | Marlins | 9–3 | Alexander (4–3) | Cronin (2–3) | — | 17,931 | 55–52 | W3 |
| 108 | July 31 | Marlins | 2–6 | Muñoz (2–5) | Bradley (6–5) | — | 14,484 | 55–53 | L1 |
|
August: 12–15 (Home: 5–6; Away: 7–9)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 109 | August 2 | @ Astros | 2–3 | Abreu (2–1) | Kelly (3–2) | Hader (22) | 33,430 | 55–54 | L2 |
| 110 | August 3 | @ Astros | 6–1 | Littell (5–7) | Blanco (9–6) | — | 37,328 | 56–54 | W1 |
| 111 | August 4 | @ Astros | 1–0 | Alexander (5–3) | Arrighetti (4–10) | Fairbanks (21) | 35,205 | 57–54 | W2 |
| 112 | August 6 | @ Cardinals | 3–4 | Gray (11–6) | Springs (0–1) | Helsley (35) | 32,922 | 57–55 | L1 |
| 113 | August 7 | @ Cardinals | 2–5 | Fedde (8–5) | Bradley (6–6) | Helsley (36) | 31,401 | 57–56 | L2 |
| 114 | August 8 | @ Cardinals | 6–4 | Lovelady (3–4) | Romero (5–2) | Fairbanks (22) | 35,217 | 58–56 | W1 |
| 115 | August 9 | Orioles | 1–4 | Eflin (8–7) | Littell (5–8) | — | 20,673 | 58–57 | L1 |
| 116 | August 10 | Orioles | 5–7 | Smith (4–0) | Poche (1–2) | Domínguez (2) | 23,898 | 58–58 | L2 |
| 117 | August 11 | Orioles | 2–1 | Rodríguez (2–2) | Kimbrel (6–4) | Fairbanks (23) | 16,848 | 59–58 | W1 |
| 118 | August 12 | Astros | 1–6 | Valdez (12–5) | Bradley (6–7) | — | 10,540 | 59–59 | L1 |
| 119 | August 13 | Astros | 2–3 | Kikuchi (6–9) | Baz (0–2) | Hader (26) | 12,275 | 59–60 | L2 |
| 120 | August 14 | Astros | 1–2 (10) | Hader (5–6) | Cleavinger (7–3) | — | 12,493 | 59–61 | L3 |
| 121 | August 16 | Diamondbacks | 5–4 | Fairbanks (3–3) | Martínez (5–3) | — | 21,613 | 60–61 | W1 |
| 122 | August 17 | Diamondbacks | 6–1 | Springs (1–1) | Gallen (9–6) | Lovelady (1) | 17,708 | 61–61 | W2 |
| 123 | August 18 | Diamondbacks | 8–7 (12) | Uceta (1–0) | Martínez (5–4) | — | 18,636 | 62–61 | W3 |
| 124 | August 19 | @ Athletics | 0–3 | Boyle (3–5) | Bradley (6–8) | Miller (19) | 3,938 | 62–62 | L1 |
| 125 | August 20 | @ Athletics | 1–0 | Baz (1–2) | Estes (5–6) | Uceta (1) | 4,377 | 63–62 | W1 |
| 126 | August 21 | @ Athletics | 4–2 | Pepiot (7–5) | Spence (7–9) | Rodríguez (1) | 10,339 | 64–62 | W2 |
| 127 | August 22 | @ Athletics | 1–3 | Bido (5–3) | Springs (1–2) | Miller (20) | 5,142 | 64–63 | L1 |
| 128 | August 23 | @ Dodgers | 3–7 | Kopech (4–8) | Rodríguez (2–3) | — | 45,556 | 64–64 | L2 |
| 129 | August 24 | @ Dodgers | 9–8 (10) | Rodríguez (3–3) | Kelly (1–1) | Cleavinger (4) | 48,488 | 65–64 | W1 |
| 130 | August 25 | @ Dodgers | 1–3 | Treinen (6–3) | Lovelady (3–5) | Banda (2) | 52,464 | 65–65 | L1 |
| 131 | August 26 | @ Mariners | 1–5 | Miller (10–7) | Pepiot (7–6) | — | 29,755 | 65–66 | L2 |
| 132 | August 27 | @ Mariners | 3–2 | Uceta (2–0) | Chargois (2–1) | Rodríguez (2) | 26,153 | 66–66 | W1 |
| 133 | August 28 | @ Mariners | 2–6 | Castillo (11–12) | Alexander (5–4) | — | 35,131 | 66–67 | L1 |
| 134 | August 30 | Padres | 5–13 | Pérez (4–5) | Bradley (6–9) | — | 17,547 | 66–68 | L2 |
| 135 | August 31 | Padres | 11–4 | Baz (2–2) | Vásquez (4–7) | — | 16,600 | 67–68 | W1 |
|
September: 13–14 (Home: 7–4; Away: 6–10)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 136 | September 1 | Padres | 3–4 | Scott (9–5) | Rodríguez (3–4) | Suárez (30) | 17,494 | 67–69 | L1 |
| 137 | September 2 | Twins | 4–5 | Alcalá (4–3) | Littell (5–9) | Durán (21) | 11,636 | 67–70 | L2 |
| 138 | September 3 | Twins | 2–1 | Springs (2–2) | Festa (2–5) | Cleavinger (5) | 10,531 | 68–70 | W1 |
| 139 | September 4 | Twins | 9–4 | Alexander (6–4) | Varland (0–6) | — | 11,513 | 69–70 | W2 |
| 140 | September 5 | Twins | 3–4 | López (14–8) | Bradley (6–10) | Durán (22) | 10,584 | 69–71 | L1 |
| 141 | September 6 | @ Orioles | 0–2 | Kremer (7–9) | Baz (2–3) | Domínguez (9) | 25,439 | 69–72 | L2 |
| 142 | September 7 | @ Orioles | 7–1 | Pepiot (8–6) | Eflin (10–8) | — | 34,256 | 70–72 | W1 |
| 143 | September 8 | @ Orioles | 2–0 | Littell (6–9) | Burnes (13–8) | Uceta (2) | 29,519 | 71–72 | W2 |
| 144 | September 9 | @ Phillies | 1–2 | Estévez (4–4) | Cleavinger (7–4) | — | 39,511 | 71–73 | L1 |
| 145 | September 10 | @ Phillies | 4–9 | Alvarado (2–5) | Lovelady (3–6) | — | 40,088 | 71–74 | L2 |
| 146 | September 11 | @ Phillies | 2–3 | Wheeler (15–6) | Rasmussen (0–1) | Estévez (25) | 40,715 | 71–75 | L3 |
| 147 | September 12 | @ Guardians | 5–2 | Sulser (1–0) | Williams (3–9) | Lovelady (2) | 19,188 | 72–75 | W1 |
| 148 | September 13 | @ Guardians | 3–1 | Littell (7–9) | Bibee (11–8) | Uceta (3) | 24,160 | 73–75 | W2 |
| 149 | September 14 | @ Guardians | 1–6 | Cantillo (2–3) | Alexander (6–5) | — | 31,362 | 73–76 | L1 |
| 150 | September 15 | @ Guardians | 0–2 | Lively (12–9) | Bradley (6–11) | Clase (45) | 21,144 | 73–77 | L2 |
| 151 | September 17 | Red Sox | 8–3 | Baz (3–3) | Pivetta (5–11) | — | 12,169 | 74–77 | W1 |
| 152 | September 18 | Red Sox | 1–2 | Slaten (6–2) | Rasmussen (0–2) | Jansen (27) | 12,153 | 74–78 | L1 |
| 153 | September 19 | Red Sox | 2–0 | Littell (8–9) | Bello (14–8) | Cleavinger (6) | 13,120 | 75–78 | W1 |
| 154 | September 20 | Blue Jays | 1–0 | Kelly (4–2) | Berríos (16–10) | Bigge (1) | 14,372 | 76–78 | W2 |
| 155 | September 21 | Blue Jays | 3–2 | Bradley (7–11) | Rodríguez (1–7) | Rasmussen (1) | 20,704 | 77–78 | W3 |
| 156 | September 22 | Blue Jays | 4–3 | Kelly (5–2) | Cabrera (3–3) | Uceta (4) | 20,567 | 78–78 | W4 |
| 157 | September 24 | @ Tigers | 1–2 | Skubal (18–4) | Pepiot (8–7) | Brieske (1) | 22,770 | 78–79 | L1 |
| 158 | September 25 | @ Tigers | 1–7 | Guenther (3–0) | Littell (8–10) | — | 32,463 | 78–80 | L2 |
| 159 | September 26 | @ Tigers | 3–4 | Brieske (4–4) | Cleavinger (7–5) | Foley (27) | 27,867 | 78–81 | L3 |
| 160 | September 27 | @ Red Sox | 2–1 | Bradley (8–11) | Pivetta (6–12) | Uceta (5) | 33,694 | 79–81 | W1 |
| 161 | September 28 | @ Red Sox | 7–2 | Baz (4–3) | Crawford (9–16) | — | 35,333 | 80–81 | W2 |
| 162 | September 29 | @ Red Sox | 1–3 | Priester (3–6) | Pepiot (8–8) | Slaten (2) | 34,862 | 80–82 | L1 |
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