RAB3GAP2

Rab3 GTPase-activating protein non-catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP2 gene.^[5][6][7]

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RAB3GAP2
Identifiers
Aliases	RAB3GAP2, RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150, RAB3 GTPase activating non-catalytic protein subunit 2, MARTS1
External IDs	OMIM: 609275; MGI: 1916043; HomoloGene: 40842; GeneCards: RAB3GAP2; OMA:RAB3GAP2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q41 Start 220,148,293 bp[1] End 220,272,529 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H5 Start 184,936,314 bp[2] End 185,018,956 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus lateral nuclear group of thalamus spinal ganglia pericardium trigeminal ganglion Pons Brodmann area 46 cardia beta cell endothelial cell Top expressed in zygote secondary oocyte granulocyte dentate gyrus of hippocampal formation granule cell substantia nigra facial motor nucleus primary oocyte superior frontal gyrus primary visual cortex decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme regulator activity enzyme activator activity GTPase activator activity protein heterodimerization activity protein binding Cellular component plasma membrane endoplasmic reticulum membrane cytoplasm cytosol protein-containing complex Biological process regulation of GTPase activity positive regulation of protein lipidation establishment of protein localization to endoplasmic reticulum membrane intracellular protein transport positive regulation of autophagosome assembly positive regulation of endoplasmic reticulum tubular network organization positive regulation of catalytic activity positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25782 98732 Ensembl ENSG00000118873 ENSMUSG00000039318 UniProt Q9H2M9 Q8BMG7 RefSeq (mRNA) NM_012414 NM_001163754 NM_172649 RefSeq (protein) NP_036546 NP_001157226 NP_001392257 Location (UCSC) Chr 1: 220.15 – 220.27 Mb Chr 1: 184.94 – 185.02 Mb PubMed search [3] [4]
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Members of the RAB3 protein family (see RAB3A; MIM 179490) are implicated in Ca(2+)-dependent exocytosis. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit (RAB3GAP1; MIM 602536) and a 150-kD noncatalytic subunit (RAB3GAP2) (Nagano et al., 1998).[supplied by OMIM]^[7]